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ProGly Mechanism

Imagine a world where we are can reeducate the immune system to help patients live better lives

The ProGly platform chemistry comprises glycan-containing NSAAs that can induce or inhibit an immune reaction. The GRO platform enables precise placement of defined ProGly compositions on the protein surface necessary to elicit a defined immune response. The Company’s first ProGly NSAAs reeducate the immune system to treat a protein as “self” or “non-self” — a totally new modality for eliminating autoimmunity and anti-drug antibodies.

Learn more about our initial indications addressing high unmet medical need.

ProGly Indications

GRObio is applying its platform to areas where there is high unmet medical need focused primarily on two broad sets of applications

Reversing Autoimmune Disease

Autoimmune disease occurs when a person’s immune system inappropriately perceives one or more “self” proteins as foreign and mounts an immune attack against them. Currently, most autoimmune patients are treated by broadly suppressing their immune system, leaving them vulnerable to infection, cancer, and metabolic dysregulation. Further, such approaches only modify symptoms rather than treat the underlying disease.

The first autoimmune indication we are pursuing is myasthenia gravis (MG), a rare disease that causes muscle weakness because the immune system makes antibodies that block the function of a key muscle receptor called the acetylcholine receptor (AChR). Symptoms include trouble chewing and swallowing, droopy eyelids, muscle weakness, and slurred speech. Refractory patients have no disease modifying therapies available, and instead are treated by immunosuppressive agents. To fulfill this pressing unmet need, GRObio is developing ProGly-AChR – the first disease-modifying therapy for MG that is highly efficacious without immune suppression. ProGly-AChR uses our ProGly platform chemistry to produce a tolerogenic version of the AChR antigen that induces proliferation of tolerogenic immune cells, which reeducate a patient’s immune system to recognize AChR as a self-protein and reverses the autoimmune process.

Eliminating Immunogenicity

Immunogenicity arises when the immune system recognizes a therapeutic as foreign. Many enzyme, gene, and cell therapies are immunogenic, which often manifests as anti-drug antibodies (ADA) directed against the therapeutic. ADA can severely limit the efficacy of a drug and can also cause serious safety issues for patients. The problem is particularly pronounced for therapies that require chronic administration, as ADA typically increase over multiple treatments.

GRObio is eliminating immunogenicity from therapeutics by creating versions that display our tolerogenic ProGly NSAAs. ProGly NSAAs serve two functions: (1) to educate the immune system to recognize the therapy as a self-protein, and (2) to prevent pre-existing ADA from binding to the therapy. We use the computational protein design tools and high-throughput screening workflows in our Biofoundry to engineer ProGly therapies that are tolerogenic while retaining their full activity in the intended physiological environment. We have shown that this approach can be applied to highly immunogenic proteins to prevent ADA, to block pre-existing ADA from binding to ProGly therapies, and to prolong their circulating time and functional half-life. We are now extending our work to address the immunogenicity of additional enzyme, gene and cell therapies.

DuraLogic

Open the doors to treatments with unprecedented duration of action as well as safer and more convenient administration

GRObio’s DuraLogic™ NSAA chemistries resolve longstanding problems with protein structural instability to provide therapies with fewer side effects and longer half-life.

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ProGly

Imagine a world where we can reeducate the immune system to help patients live better lives

We leverage our ProGly™ NSAA chemistries to eliminate autoimmune reactions, and to prevent development of anti-drug antibodies that make treatment ineffective for patients.

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Additional Chemistries

GRObio has access to an entire universe of new therapeutic capabilities provided by non-standard amino acids (NSAAs)

See how GRObio taps into the universe of non-standard amino acids (NSAAs) to address pressing unmet clinical needs.

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