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One year, 1 lab, 16 spinouts

In the early 2000s, Jay Shendure was a graduate student in George Church’s lab at Harvard University. Back then, he says, there was “hardly an inkling” that the lab would become a hotbed of startup activity.

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Aditya M Kunjapur, Michael G Napolitano, Eriona Hysolli, Karen Noguera, Evan M Appleton, Max G Schubert, Michaela A Jones, Siddharth Iyer, Daniel J Mandell, George M Church. Synthetic auxotrophy remains stable after continuous evolution and in coculture with mammalian cells. Sci Adv, 2021 Jul (27):eabf5851. doi: 10.1126/sciadv.abf5851. Print 2021 Jul.

https://pubmed.ncbi.nlm.nih.gov/34215581/

Glasgow AA, Huang YM, Mandell DJ, Thompson M, Ritterson R, Loshbaugh AL, Pellegrino J, Krivacic C, Pache RA, Barlow KA, Ollikainen N, Jeon D, Kelly MJS, Fraser JS, Kortemme T (2019) Computational design of a modular protein sense-response system. Science, 366(6468):1024-1028. PMID: 31754004.

https://www.science.org/doi/full/10.1126/science.aax8780

Napolitano MG, Gregg CJ, Lajoie MJ, Landon MM, Govindarajan LN, Mosberg JA, Kuznetsov G, Goodman DB, Vargas O, Isaacs FJ, Soll D, Church GM (2015) Emergent rules for codon choice elucidated by editing rare arginine codons in E. coli. PNAS. PMID: 27601680

https://pubmed.ncbi.nlm.nih.gov/27601680/

Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner C, Tyree G, Gonzales A, Wanner BL, Norville J, Lajoie MJ, Church GM (2016) Design, Synthesis and Testing Towards a 57-Codon Genome. Science 353(6301):819-22. PMID: 27540174

https://pubmed.ncbi.nlm.nih.gov/27540174/

Zheng Y, Lajoie MJ, Italia JS, Chin M, Church GM, Chatterjee A (2016) Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1. Mol Biosyst. 2016 Mar 30. PMID: 27027374

https://pubmed.ncbi.nlm.nih.gov/27027374/

Feng J, Jester BW, Tinberg CE, Mandell DJ, Antunes MS, Chari R, Morey KJ, Rios X, Medford JI, Church GM, Fields S, Baker D (2015). A general strategy to construct small molecule biosensors in eukaryotes. eLife, 4(e10606). PMID: 2671411

https://pubmed.ncbi.nlm.nih.gov/26714111/

Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville J, Gregg CJ, Stoddard BL, Church GM (2015) Biocontainment of genetically modified organisms by synthetic protein design. Nature. PMID: 25607366

https://pubmed.ncbi.nlm.nih.gov/25607366/

Thyer R, Robotham SA, Brodbelt JS, Ellington AD (2015) Evolving tRNA(Sec) for efficient canonical incorporation of selenocysteine. J Am Chem Soc 137, 46-49. PMID: 25521771

https://pubmed.ncbi.nlm.nih.gov/25521771/

Gregg CJ, Lajoie MJ, Napolitano MG, Mosberg JA, Goodman DB, Aach J, Isaacs FJ, Church GM (2014) Rational Optimization of tolC as a Powerful Dual Selectable Marker for Genome Engineering. Nucleic Acids Research. PMID: 24452804

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985617/

Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FI (2013) Genomically Recoded Organisms Impart New Biological Functions. Science 342: 357-60. PMID: 24136966

https://pubmed.ncbi.nlm.nih.gov/24136966/

Lajoie MJ, Kosuri S, Mosberg JA, Gregg CJ, Zhang D, Church GM (2013) Probing the limits of genetic recoding in essential genes. Science 342: 361-3. PMID: 24136967

https://pubmed.ncbi.nlm.nih.gov/24136967/